Reproduction Abstracts

Introduction: Pulsatile GnRH secretion is a key determinant for normal gonadal activities. Recent emerging evidence suggests that neurokinin B (NKB) plays a pivotal role in generating GnRH pulse. Here, we aimed to develop novel compounds with potent NKB receptor (NK3R) agonistic activity for future therapeutic applications to improve gonadal functions.Materials and methods: On the basis of the structure-activity relationship study of NKB and tachykinin p...